The remaining members of S.T.A.R.S. tried to get the word out about Umbrella Incorporation’s involvement with the mansion incident, and the exact nature of the undead that were advancing upon the city.

Chief Brian Irons dismissed their claims as unbelievable drug induced hallucinations. The claims of the survivors were laughed off, even as the horrors unleashed by Umbrella began their slow, unstoppable march upon Raccoon City. Soon, chaos reigned. Even as the entire city was being destroyed by unspeakable horrors, rookie cop Leon S. Kennedy sped towards Raccoon City, eager to start his duties as a police officer.

Instead of finding his comrades and a secure city, he stumbled upon a necropolis of the living dead, the only RPD officer left to serve and protect any humans who had escaped death. On the other end of the city, Claire Redfield searchs for her brother, Chris Redfield. Raccoon was where they had last met, and she is unprepared for the monsters that await her. Before long, she realizes that the sickness around Raccoon City could cost her her life, and she must escape.

While running from the undead, Claire and Leon meet up in the middle of the city. The two must figure out not only who and what is causing this epidemic, but how to survive.