Umbrella Chronicles is an on-rails shooter on the Wii. The game centers around the events of Resident Evil Zero, REmake, Resident Evil 3 and a new chapter describing Umbrella's fall.

A lot of plotholes are filled in and explored, for example, Wesker's resurrection, Ada escaping Raccoon City in Resident Evil 2, and Jill and Chris following the previous games.

It also introduces new characters and B.O.Ws, such as Talos, Sergei Vladimir, and many more. Using the Wii Remote, you can aim a pointer on the screen as if you were holding a gun. You can also upgrade your weapons by earning points, for the higher grade you get in scenarios. This is based on how many files you collect, objects shot, critical hits and enemies killed.

There is also an unlockable mini-game in which you have to shoot exploding zombies, in an unknown room; no connection to Resident Evil 5 has been confirmed thus far.